Oncology & Hematology

Radiation Therapy

Radiation therapy, also known as radiotherapy, is a common medical treatment for cancer that uses high-energy radiation to kill cancer cells and shrink tumors.
Radiation Therapy

Overview

Radiation therapy, also known as radiotherapy, is a medical treatment that uses high doses of radiation to kill cancer cells and shrink tumors. This therapy can be delivered externally using machines like linear accelerators or internally through radioactive implants. Modern techniques aim to target cancer cells precisely while minimizing damage to surrounding healthy tissues.

About Radiation Therapy

Radiation therapy, also known as radiotherapy, is a common treatment for cancer that uses high-energy radiation to kill cancer cells.

What is Radiation Therapy? 

What is Radiation Therapy? 

Radiation therapy, also known as radiotherapy, is a medical treatment that uses high doses of radiation to kill cancer cells and shrink tumors. This therapy works by damaging the DNA within cancer cells, which prevents them from growing and dividing. Over time, the damaged cancer cells die and are naturally eliminated by the body. Radiation therapy can be delivered externally or internally, depending on the type and location of the cancer.

  • External beam radiation therapy is the most common form of radiation therapy. It involves using a machine called a linear accelerator to direct high-energy beams of radiation at the cancerous area from outside the body. The machine can move around the patient to target the tumor from different angles, ensuring that the maximum dose of radiation is delivered to the cancer cells while minimizing exposure to surrounding healthy tissues.

  • Internal radiation therapy, or brachytherapy, involves placing a radioactive source directly inside or near the tumor. This method allows for a higher dose of radiation to be delivered to a more localized area, reducing the risk of damage to nearby healthy tissues. Brachytherapy is often used for cancers of the prostate, cervix, and breast.

Radiation therapy can be used at different stages of cancer treatment. It may be employed as the primary treatment to eradicate cancer, or it can be used before surgery (neoadjuvant therapy) to shrink tumors, making them easier to remove. After surgery, radiation therapy (adjuvant therapy) can help eliminate any remaining cancer cells. Additionally, it can be combined with other treatments, such as chemotherapy, to enhance the overall effectiveness.

Radiation therapy is a critical component of modern cancer treatment, with more than half of all cancer patients receiving it at some point during their treatment. Its ability to precisely target cancer cells while sparing healthy tissues makes it an invaluable option for many types of cancer. 

Types of Radiation Therapy

Types of Radiation Therapy

Radiation therapy, a cornerstone in cancer treatment, employs various techniques to target and destroy cancer cells. The two primary types of radiation therapy are external beam radiation therapy (EBRT) and internal radiation therapy.

External beam radiation therapy (EBRT) is the most prevalent form. It involves using a machine called a linear accelerator to direct high-energy beams of radiation at the cancer from outside the body. This method is highly versatile and can treat many types of cancer, including those of the brain, breast, lung, and prostate. Within EBRT, there are several advanced techniques:

  • 3D Conformal Radiation Therapy (3DCRT): This technique uses three-dimensional scans to map the exact shape and size of the tumor. Radiation beams are then shaped to match the tumor, minimizing exposure to surrounding healthy tissues.

  • Intensity-Modulated Radiation Therapy (IMRT): IMRT delivers radiation in varying intensities from multiple angles. This allows for higher doses to be concentrated on the tumor while sparing nearby healthy tissue.

  • Image-Guided Radiation Therapy (IGRT): IGRT uses imaging during treatment to improve precision. It is particularly useful for tumors that move, such as those in the lungs or liver.

  • Volumetric Modulated Arc Therapy (VMAT): VMAT delivers radiation in a continuous arc around the patient, allowing for precise targeting and reduced treatment times.

Internal radiation therapy, also known as brachytherapy, involves placing a radioactive source directly inside or near the tumor. This method is often used for cancers of the prostate, cervix, and breast. Brachytherapy allows for a high dose of radiation to be delivered to a localized area, minimizing damage to surrounding tissues.

  • Another form of internal radiation therapy is systemic radiation therapy, which involves administering radioactive substances orally or intravenously. These substances travel through the bloodstream to target cancer cells throughout the body. This approach is commonly used for thyroid cancer and certain types of lymphoma.

  • Intraoperative Radiation Therapy (IORT) is a specialized form of internal radiation given during surgery. It delivers a concentrated dose of radiation to a tumor site while sparing surrounding healthy tissues. IORT is often used for cancers that are difficult to remove completely through surgery alone.

Why is Radiation Therapy done? 

Why is Radiation Therapy done? 

Radiation therapy is a crucial treatment modality in the fight against cancer, utilized for its ability to target and destroy cancer cells with precision. The primary goal of radiation therapy is to treat cancer by damaging the DNA within cancer cells, which prevents them from growing and dividing. This treatment can be used in various stages and for different purposes in cancer management.

One of the main reasons radiation therapy is employed is as a primary treatment to eradicate cancer. In some cases, it is the sole treatment used to cure cancer, especially for localized tumors that have not spread to other parts of the body. For instance, early-stage cancers of the head and neck, prostate, and cervix can often be effectively treated with radiation therapy alone.

Radiation therapy is also used before surgery (neoadjuvant therapy) to shrink tumors, making them easier to remove surgically. This approach can increase the likelihood of a successful surgery and reduce the risk of cancer recurrence. Conversely, after surgery (adjuvant therapy), radiation therapy can help eliminate any remaining cancer cells that were not removed during the operation, thereby reducing the risk of the cancer coming back.

In addition to its curative potential, radiation therapy plays a significant role in palliative care. For patients with advanced cancer, where a cure is not possible, radiation therapy can be used to relieve symptoms and improve quality of life. It can help shrink tumors that are causing pain, pressure, or other symptoms, such as difficulty breathing or swallowing.

Radiation therapy is often combined with other treatments, such as chemotherapy, to enhance its effectiveness. This combination can be particularly beneficial in treating certain types of cancer, such as head and neck cancers, where the synergy between radiation and chemotherapy can lead to better outcomes.

Moreover, radiation therapy is not limited to cancer treatment. It can also be used to treat non-cancerous conditions, such as benign tumors and certain neurological disorders. For example, it can be used to shrink benign brain tumors or to treat trigeminal neuralgia, a chronic pain condition affecting the facial nerves.

Radiation Therapy Process

Radiation Therapy Risks & Side Effects 

Radiation therapy, while a powerful tool in cancer treatment, comes with its own set of risks and side effects. These side effects can vary widely depending on the type and location of the cancer, the dose of radiation, and the patient's overall health. Understanding these potential risks is crucial for patients undergoing this treatment.

  • One of the most common side effects of radiation therapy is fatigue. This type of fatigue is different from everyday tiredness and can be quite debilitating, affecting a patient's ability to perform daily activities. It often starts a few weeks into treatment and can persist for weeks or even months after the therapy ends.

  • Skin changes are another frequent side effect, especially in areas where the radiation is administered. Patients may experience redness, dryness, itching, or peeling of the skin, similar to a sunburn. In some cases, these changes can be more severe, leading to blistering or open sores. Proper skin care and avoiding irritants can help manage these symptoms.

  • Hair loss can occur in the area being treated, which is particularly common when the head or neck is targeted. Unlike chemotherapy, which can cause hair loss all over the body, radiation therapy typically affects only the specific area being treated.

  • Gastrointestinal issues are common when radiation is directed at the abdomen or pelvis. Patients may experience nausea, vomiting, diarrhea, or loss of appetite. These symptoms can often be managed with dietary changes and medications.

  • Long-term side effects can also occur, sometimes months or years after treatment. These can include fibrosis (the thickening and scarring of connective tissue), damage to the bowels leading to chronic diarrhea or bleeding, and even secondary cancers caused by the radiation. The risk of these long-term effects depends on the radiation dose and the specific area treated.

  • Emotional and psychological effects are also significant. The stress of undergoing cancer treatment, combined with the physical side effects, can lead to anxiety, depression, and other emotional challenges. Support from healthcare providers, counselors, and support groups can be invaluable in managing these issues.

Despite these risks, radiation therapy remains a cornerstone of cancer treatment due to its effectiveness in targeting and destroying cancer cells. 

Benefits of Radiation Therapy

Radiation therapy offers numerous benefits, making it a cornerstone in the treatment of various cancers. 

  • One of the primary advantages is its ability to target and destroy cancer cells with high precision. This precision is achieved through advanced techniques like Intensity-Modulated Radiation Therapy (IMRT) and Image-Guided Radiation Therapy (IGRT), which allow for the delivery of high doses of radiation directly to the tumor while minimizing damage to surrounding healthy tissues.

  • Radiation therapy is highly versatile and can be used at different stages of cancer treatment. It can serve as the primary treatment for certain cancers, effectively eradicating tumors without the need for surgery. For instance, early-stage cancers of the head and neck, prostate, and cervix can often be treated successfully with radiation therapy alone. Additionally, radiation therapy can be used before surgery (neoadjuvant therapy) to shrink tumors, making them easier to remove and increasing the likelihood of a successful surgical outcome. Conversely, after surgery (adjuvant therapy), it can help eliminate any remaining cancer cells, reducing the risk of recurrence.

  • Another significant benefit of radiation therapy is its role in palliative care. For patients with advanced cancer, where a cure is not possible, radiation therapy can help relieve symptoms and improve quality of life. It can shrink tumors that are causing pain, pressure, or other symptoms, such as difficulty breathing or swallowing. This symptom relief can be crucial in enhancing the patient's comfort and overall well-being.

  • Radiation therapy is also beneficial when combined with other treatments, such as chemotherapy. This combination can enhance the overall effectiveness of cancer treatment, particularly in cases where the cancer is aggressive or has spread to other parts of the body. The synergistic effect of combining radiation with chemotherapy can lead to better outcomes and increased survival rates.

Moreover, radiation therapy is not limited to cancer treatment. It can also be used to treat non-cancerous conditions, such as benign tumors and certain neurological disorders. For example, it can be used to shrink benign brain tumors or to treat trigeminal neuralgia, a chronic pain condition affecting the facial nerves.

How to Prepare for Radiation Therapy

Preparing for radiation therapy involves several important steps to ensure the treatment is as effective and comfortable as possible. The process begins with an initial consultation with a radiation oncologist, who will review your medical history and discuss whether radiation therapy is the best option for you. This is followed by a simulation session, where you will be positioned for treatment and undergo imaging, such as a CT scan, to help plan your therapy.

  • Physical preparation is crucial. It's recommended to eat a light, healthy meal a few hours before your session to maintain energy without causing discomfort. Staying hydrated is also important, so drink plenty of water before your appointment. Avoid applying lotions, perfumes, or deodorants to the treatment area, as these can irritate the skin during radiation. Wearing loose, comfortable clothing can help minimize any discomfort or irritation.

  • Emotional and mental preparation is equally important. Radiation therapy can be a stressful experience, so finding ways to relax and manage anxiety is beneficial. Techniques such as deep breathing, meditation, or listening to calming music can help. Bringing a friend or family member for support can also make the experience less daunting.

  • Logistical preparation involves planning for transportation and daily routines. Since radiation therapy often requires multiple sessions over several weeks, arranging reliable transportation to and from the treatment centre is essential. If you feel anxious or unwell, having someone to drive you can be very helpful. Additionally, organizing help at home for daily tasks can reduce stress and allow you to focus on your treatment and recovery.

  • Medical preparation includes discussing any current medications with your healthcare team to ensure they do not interfere with the treatment. It's also important to address any concerns about fertility, as some types of radiation therapy can affect reproductive health. Your doctor may recommend specific measures to protect your fertility if this is a concern.

  • Skin care is another critical aspect. Radiation can cause skin irritation, so taking care of your skin is vital. Avoiding sun exposure, using gentle skin care products, and following any specific instructions from your healthcare team can help manage and prevent skin issues.

Overall, thorough preparation for radiation therapy can help minimize side effects and improve the effectiveness of the treatment. 

Radiation Therapy in Iran

Equipped hospitals and advanced specialized centers with experienced doctors and specialists are available in all medical treatment areas in Iran. Also, good hotels and entertainment centers have made Iran an appropriate choice for patients who suffer from cancer and need Radiation Therapy.

Radiation Therapy cost in Iran

The cost of radiation therapy in Iran can vary significantly based on several factors, including the type of cancer, the specific treatment required, and the healthcare facility providing the service. Generally, Iran offers relatively affordable cancer treatment options compared to many other countries, making it an attractive destination for medical tourism.

Radiation therapy costs in Iran are influenced by whether the treatment is provided in a public, private, or charity-based center. This makes radiation therapy accessible to a broader segment of the population, ensuring that even those with limited financial resources can receive necessary treatment.

Private centers, on the other hand, tend to be more expensive due to the higher quality of services and advanced technologies they offer. The cost in these centers can vary widely, but it generally ranges from 2000-5000 USD per cycle of treatment. This price range is still relatively lower compared to many Western countries, where similar treatments can cost significantly more.

The type of radiation therapy also affects the cost. For example, advanced techniques like Intensity-Modulated Radiation Therapy (IMRT) and Image-Guided Radiation Therapy (IGRT) are more expensive than conventional methods due to the sophisticated equipment and expertise required. However, these advanced techniques offer better precision and fewer side effects, which can be crucial for certain types of cancer.

Radiation Therapy in Iran
Radiation Therapy in Iran
Radiation Therapy in Iran
Radiation Therapy in Iran

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FAQs

Radiation therapy is a medical treatment that uses high doses of radiation to kill cancer cells and shrink tumors.

It works by damaging the DNA within cancer cells, preventing them from growing and dividing. Over time, the damaged cancer cells die and are naturally eliminated by the body.

The side effects of radiation therapy can vary depending on the area being treated and the dose of radiation used. Common side effects include fatigue, skin irritation (such as redness, dryness, or peeling), and hair loss at the treatment site. Other side effects may include nausea, vomiting, diarrhea, and loss of appetite if the abdomen or pelvis is treated.

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